Resistance is futile: Targeting multidrug-resistant bacteria with de novo Cys-rich cyclic polypeptides

Multidrug-resistant bacteria: what is the threat?

Despite big advances in antimicrobial therapies and infection strategies, the emergence of antibiotic resistance represents an emergency situation, especially in immunocompromised hosts. Specifically, infections due to multidrug resistant, gram-negative pathogens are responsible for high mortality rates and may leave few effective antimicrobial options. Furthermore, although new compounds are a...

Resistance is Futile

The Lemonade Game is a three-player game in which players have to pick locations on a circular board, which are as far away as possible from those chosen independently by other players. Players may observe other player’s moves and infer their strategies. The game was studied using a competition of cognitively motivated agents, which inherit properties of adaptivity and stochasticity from human ...

Resistance Is Futile.

New Antibiotics—Resistance Is Futile

PLoS Biology | http://biology.plosjournals.org By next summer, more than 40% of Streptococcus pneumoniae strains in the United States will resist both penicillin and erythromycin, according to a recent prediction from the Harvard School of Public Health. The forecast, based on mathematical modeling, was published in the spring of 2003. It’s too early to tell whether that prediction is precisely...

Prospects for Success in Inhibiting the Growth of Multidrug-resistant Bacteria with Paromomycin

Streptomyces is the most important bacterial genus known to produce secondary antibiotic compounds. Considering the speed of bacterial resistance spread, it becomes more important to study less used compounds. Aminoglycosides disrupt the function of the target microorganism by acting on the protein-synthesis process. Paromomycin is an aminoglycoside that acts on a wide range of gram-positive, g...